RiverCruiseUSA.com
Powered by Vacations To Go, with over 8 million happy customers since 1984
800-510-4002|My Account
Mississippi River

Explore America's historic treasures on a cruise of the Mississippi River, a 2,320-mile waterway that flows through 10 states, from Minnesota to the Gulf of Mexico. Sailings on the Mississippi visit Civil War battlefields, restored plantations, rolling farmland and picturesque riverfront towns filled with Victorian-era architecture. 

Mississippi River cruises are easy to budget, as the upfront price covers accommodations, delectable meals, wine and beer with dinner, onboard entertainment and enriching lectures. A tour of local attractions at each port is also included.

Find Your Next Vacation





Limited-Time Offers: Mississippi River
Offers are subject to change or withdrawal at any time. Some discounts are not combinable with other promotions.
  • Save up to $2,200 per couple off 2020 American Queen Steamboat Company cruises. Enjoy additional savings in higher cabin categories. Click here.
  • Book 2021 sailings at 2020 prices, plus save up to an additional $600 per couple in certain cabin categories with American Queen Steamboat Company. Click here.
  • Save up to $2,000 per couple off select American Cruise Lines sailings. Click here.
  • Save $400 per couple off American Cruise Lines departures when you book nine months in advance. Click here.
  • Receive one free hotel night before your cruise with American Cruise Lines, plus transfers to your ship on the day of departure when you book one month in advance. Click here.
  • Receive free shore excursions on select American Cruise Lines river cruises. Click here.
  • Enjoy a free open-bar cocktail hour every evening before dinner with American Cruise Lines. Click here.
  • Enjoy free shore excursions on every sailing with American Queen Steamboat Company. Click here.

Mississippi River (To view the full itinerary, dates and prices, click "See prices.")
Vacation name Days Begins in Ends in Company Quality From
Highlights of the Mississippi River 5 New Orleans,
LA
New Orleans,
LA
ACL Deluxe See prices
Roundtrip New Orleans 2021 (6 Day, American Countess) 6 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Lower Mississippi River Cruise (New Orleans to Memphis) 8 New Orleans,
LA
Memphis,TN ACL Deluxe See prices
Antebellum South (New Orleans to Memphis, American Countess) 8 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Antebellum South (Memphis to New Orleans, American Countess) 8 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Southern Sampler (New Orleans Roundtrip, American Countess) 8 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Antebellum South (Memphis to New Orleans, American Countess) 8 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
American River BBQ Challenge (American Countess, Memphis to Alton/St. Louis) 8 Memphis,TN Alton,
IL
Steamboat Deluxe See prices
Roundtrip Red Wing (Minneapolis) 2021 (American Duchess) 8 Minneapolis,
MN
Red Wing,
MN
Steamboat Deluxe See prices
New Year's Celebration (New Orleans Roundtrip, American Countess) 8 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Civil War (American Countess, Chattanooga to Memphis) 8 Chattanooga,
TN
Memphis,TN Steamboat Deluxe See prices
Mark Twain's Mississippi (Alton/St. Louis to Red Wing/Minneapolis) 8 St. Louis,
MO
Red Wing,
MN
Steamboat Deluxe See prices
Civil War (American Countess, Memphis to Chattanooga) 8 Memphis,TN Chattanooga,
TN
Steamboat Deluxe See prices
Mark Twain's Mississippi (American Countess, Red Wing/Minneapolis to Alton/St. Louis) 8 Red Wing,
MN
Alton,
IL
Steamboat Deluxe See prices
New Year's Celebration (New Orleans Roundtrip, American Duchess) 8 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Alton (St. Louis) to Red Wing (Minneapolis) 2021 (American Duchess) 8 St. Louis,
MO
Red Wing,
MN
Steamboat Deluxe See prices
Mark Twain's Mississippi (Red Wing/Minneapolis to Alton/St. Louis, American Duchess) 8 Minneapolis,
MN
Alton,
IL
Steamboat Deluxe See prices
Mark Twain's Mississippi (Alton/St. Louis to Red Wing/Minneapolis, American Duchess) 8 St. Louis,
MO
Red Wing,
MN
Steamboat Deluxe See prices
Mississippi River Cruise (New Orleans Roundtrip) 8 New Orleans,
LA
New Orleans,
LA
ACL Deluxe See prices
Upper Mississippi River Cruise (St. Louis to St. Paul) 8 St. Louis,
MO
St. Paul,
MN
ACL Deluxe See prices
Mark Twain Upper Mississippi River Cruise (St. Louis to St. Paul) 8 St. Louis,
MO
St. Paul,
MN
ACL Deluxe See prices
Cumberland River Cruise (Fall Foliage, Nashville to St. Louis) 8 Nashville,
TN
St. Louis,
MO
ACL Deluxe See prices
Upper Mississippi River Cruise (St. Paul to St. Louis) 8 St. Paul,
MN
St. Louis,
MO
ACL Deluxe See prices
Cumberland River Cruise (Fall Foliage, St. Louis to Nashville) 8 St. Louis,
MO
Nashville,
TN
ACL Deluxe See prices
Lower Mississippi River Cruise (Memphis to New Orleans) 8 Memphis,TN New Orleans,
LA
ACL Deluxe See prices
Mississippi River Cruise (Christmas Cruise, New Orleans Roundtrip) 8 New Orleans,
LA
New Orleans,
LA
ACL Deluxe See prices
Mississippi River Cruise (New Years Cruise, New Orleans Roundtrip) 8 New Orleans,
LA
New Orleans,
LA
ACL Deluxe See prices
Lower Mississippi River Cruise (Thanksgiving Cruise, Memphis to New Orleans) 8 Memphis,TN New Orleans,
LA
ACL Deluxe See prices
Antebellum South 2021 (Memphis to New Orleans, American Duchess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Antebellum South 2021 (New Orleans to Memphis, American Duchess) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Plantation Holidays (American Queen, New Orleans to Memphis) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Plantation Holidays (American Queen, Memphis to New Orleans) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Southern Sampler (American Queen) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Memphis to New Orleans 2021 (9 Day, American Queen) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Antebellum South (Memphis to New Orleans, American Queen) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Roundtrip New Orleans 2021 (9 Day, American Countess) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Antebellum South 2021 (Memphis to New Orleans, American Countess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Creole Christmas (American Queen) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
New Orleans to Memphis 2021 (9 Day, American Queen) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
American Culinary Experience 2021 (St. Louis to Cincinnati, American Duchess) 9 St. Louis,
MO
Cincinnati,
OH
Steamboat Deluxe See prices
Antebellum South 2021 (New Orleans to Memphis, American Countess) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Roundtrip New Orleans 2021 (9 Day, American Queen) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
New Year's Celebration (American Queen) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Antebellum South (New Orleans to Memphis, American Queen) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
American River BBQ Challenge (American Queen, Memphis to Alton/St. Louis) 9 Memphis,TN Alton,
IL
Steamboat Deluxe See prices
Plantation Thanksgiving (New Orleans to Memphis) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Louisville to Alton 2021 (American Duchess) 9 Louisville,
KY
Alton,
IL
Steamboat Deluxe See prices
Southern Sampler 2021 (New Orleans Roundtrip, American Duchess) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Alton (St. Louis) to Memphis 2021 (American Duchess) 9 St. Louis,
MO
Memphis,TN Steamboat Deluxe See prices
Mardi Gras on the River (American Queen) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Louisville to Pittsburgh 2021 (9 Day, American Queen) 9 Louisville,
KY
Pittsburgh,
PA
Steamboat Deluxe See prices
Civil War (Memphis to New Orleans, American Queen) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Louisville to Memphis 2021 (9 Day, American Queen) 9 Louisville,
KY
Memphis,TN Steamboat Deluxe See prices
American River BBQ Challenge 2021 (Memphis to Alton/St. Louis, American Countess) 9 Memphis,TN Alton,
IL
Steamboat Deluxe See prices
Chattanooga to Memphis 2021 (9 Day, American Queen) 9 Chattanooga,
TN
Memphis,TN Steamboat Deluxe See prices
Louisville to Alton/St. Louis 2021 (9 Day, American Queen) 9 Louisville,
KY
Alton,
IL
Steamboat Deluxe See prices
Plantation Holidays (New Orleans to Memphis, American Duchess) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
Plantation Holidays (Memphis to New Orleans, American Duchess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
American Culinary Experience (St. Louis to Cincinnati, American Duchess) 9 St. Louis,
MO
Cincinnati,
OH
Steamboat Deluxe See prices
Memphis to Chattanooga 2021 (9 Day, American Queen) 9 Memphis,TN Chattanooga,
TN
Steamboat Deluxe See prices
Memphis to Louisville 2021 (9 Day, American Queen) 9 Memphis,TN Louisville,
KY
Steamboat Deluxe See prices
Pittsburgh to Louisville 2021 (9 Day, American Queen) 9 Pittsburgh,
PA
Louisville,
KY
Steamboat Deluxe See prices
Antebellum South (New Orleans to Memphis, American Duchess) 9 New Orleans,
LA
Memphis,TN Steamboat Deluxe See prices
American River BBQ Challenge (Memphis to Alton/St. Louis, American Duchess) 9 Memphis,TN Alton,
IL
Steamboat Deluxe See prices
Mark Twain's Mississippi (American Queen, Alton/St. Louis to Red Wing/Minneapolis) 9 Alton,
IL
Red Wing,
MN
Steamboat Deluxe See prices
American River BBQ Challenge (St. Louis/Alton to Memphis, American Duchess) 9 St. Louis,
MO
Memphis,TN Steamboat Deluxe See prices
Antebellum South (Memphis to New Orleans, American Duchess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Mark Twain's Mississippi (American Queen, Red Wing/Minneapolis to Alton/St. Louis) 9 Minneapolis,
MN
Alton,
IL
Steamboat Deluxe See prices
Heartland Heritage (Red Wing/Minneapolis Roundtrip, American Duchess) 9 Minneapolis,
MN
Red Wing,
MN
Steamboat Deluxe See prices
Creole Christmas (American Duchess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Memphis to Chattanooga 2021 (American Duchess) 9 Memphis,TN Chattanooga,
TN
Steamboat Deluxe See prices
Chattanooga to Memphis 2021 (American Duchess) 9 Chattanooga,
TN
Memphis,TN Steamboat Deluxe See prices
Alton/St. Louis to Red Wing/Minneapolis 2021 (9 Day, American Queen) 9 St. Louis,
MO
Red Wing,
MN
Steamboat Deluxe See prices
Mark Twain's Mississippi 2021 (Alton/St. Louis to Red Wing/Minneapolis, American Countess) 9 St. Louis,
MO
Red Wing,
MN
Steamboat Deluxe See prices
St. Louis to New Orleans 2021 (9 Day, American Countess) 9 St. Louis,
MO
New Orleans,
LA
Steamboat Deluxe See prices
Plantation Thanksgiving (Memphis to New Orleans, American Duchess) 9 Memphis,TN New Orleans,
LA
Steamboat Deluxe See prices
Red Wing/Minneapolis to St. Louis (9 Day, American Countess) 9 Minneapolis,
MN
St. Louis,
MO
Steamboat Deluxe See prices
Civil War 2021 (Memphis to Chattanooga, American Countess) 9 Memphis,TN Chattanooga,
TN
Steamboat Deluxe See prices
Civil War 2021 (Chattanooga to Memphis, American Countess) 9 Chattanooga,
TN
Memphis,TN Steamboat Deluxe See prices
St. Louis to Memphis 2021 (American Duchess) 9 St. Louis,
MO
Memphis,TN Steamboat Deluxe See prices
Louisville to St. Louis 2021 (American Duchess) 9 Louisville,
KY
St. Louis,
MO
Steamboat Deluxe See prices
Kentucky Derby Cruise 2021 (American Duchess) 9 Cincinnati,
OH
Louisville,
KY
Steamboat Deluxe See prices
American Music Cruise (Nashville to Memphis, American Duchess) 9 Nashville,
TN
Memphis,TN Steamboat Deluxe See prices
Southern Sampler (New Orleans Roundtrip, American Duchess) 9 New Orleans,
LA
New Orleans,
LA
Steamboat Deluxe See prices
Kentucky Derby Cruise (American Duchess) 9 Cincinnati,
OH
Louisville,
KY
Steamboat Deluxe See prices
Mississippi River Gateway Cruise (New Orleans to St. Louis) 11 New Orleans,
LA
St. Louis,
MO
ACL Deluxe See prices
The Mighty Mississippi (Red Wing to New Orleans, American Countess) 15 Red Wing,
MN
New Orleans,
LA
Steamboat Deluxe See prices
Grand Heartland Cruise 15 St. Paul,
MN
New Orleans,
LA
ACL Deluxe See prices
The Mighty Mississippi (American Queen, Red Wing/Minneapolis to New Orleans) 16 Minneapolis,
MN
New Orleans,
LA
Steamboat Deluxe See prices
The Mighty Mississippi (Red Wing/Minneapolis to New Orleans, American Duchess) 16 Minneapolis,
MN
New Orleans,
LA
Steamboat Deluxe See prices
Complete Mississippi River Cruise 22 New Orleans,
LA
St. Paul,
MN
ACL Deluxe See prices
The Mighty Mississippi (New Orleans to Red Wing, American Duchess) 23 New Orleans,
LA
Red Wing,
MN
Steamboat Deluxe See prices